针对肉羊种业“卡脖子”问题,重点关注湖羊特色性状关键基因挖掘及新品系培育工作。前期围绕高低繁湖羊下丘脑-垂体-卵巢(卵泡)-子宫轴,利用10×Genomics、RNA-Seq、WGBS、全基因组重测序(WGS)、乳酸化修饰组学和蛋白质组学等多组学技术从转录和翻译层面进行了系统性的筛选和功能验证,鉴定了多个与湖羊优异性状相关的关键基因及信号通路,相关成果以第一作者在《Mol Ther-Nucl Acids》、《FASEB J》、《Front Cell Dev Biol》、《Genomics》、《Reproduction》、《Theriogenology》、南京农业大学学报、畜牧兽医学报等学科主流期刊上发表10余篇(IF>10 SCI论文1篇,学科前Top 10% SCI论文5篇,学科前Top20%SCI论文8篇);授权2项软件著作权和1项发明专利。近三年代表作如下: [1] Xiaolei Yao, Xiaoxiao Gao, Yongjin Bao, M.A.EI-Samahy, Jinyu Yang, Zhibo Wang, Xiaodan Li, Guomin Zhang, Yanli Zhang, Wujun Liu, Feng Wang*. lncRNA FDNCR promotes apoptosis of granulosa cells by targeting the miR-543-3p/DCN/TGF-β signaling pathway in Hu sheep. Mol Ther-Nucl Acids, 2021, 24(4):223-240. [2] Yao X, El-Samahy MA, Li X, Bao Y, Guo J, Yang F, Wang Z, Li K, Zhang Y, Wang F*. LncRNA-412.25 activates the LIF/STAT3 signaling pathway in ovarian granulosa cells of Hu sheep by sponging miR-346. FASEB J, 2022, 00: e22467. [3] Xiaolei Yao, Fengzhe Li, Zongyou Wei, M. A. EI-Samahy, Xu Feng, Fan Yang, Feng Wang*. Integrative Genome-Wide DNA Methylome and Transcriptome Analysis of Ovaries from Hu Sheep with High and Low Prolific. Front Cell Dev Biol, 2022, 10:820558. [4] Xiaolei Yao, Fan Yang, M.A. El-Samahy, Bin Liu, Bingru Zhao, Xiaoxiao Gao, Jian Zheng, Xu Feng, Yixuan Fan, Feng Wang, Yanli Zhang*. Identification and characterization of unique and common lncRNAs and mRNAs in the pituitary, ovary, and uterus of Hu sheep with different prolificacy. Genomics, 2022, 114(6): 110511. [5] Xiaolei Yao, M A EI-Samahy, Shenhua Xiao, Zhibo Wang, Fanxing Meng, Xiaodan Li, Yongjin Bao, Yanli Zhang, Ziyu Wang, Yixuan Fan, Feng Wang*. CITED4 mediates proliferation, apoptosis and steroidogenesis of Hu sheep granulosa cells in vitro. Reproduction, 2021,161 255-267. [6] Xiaolei Yao#, Zhibo Wang#, Xiaoxiao Gao, Xiaodan Li, Hua Yang, M.A. Ei-Samahy, Yongjin Bao, Shenhua Xiao, Fanxing Meng, Feng Wang*. Unconservative_15_2570409 suppresses progesterone receptor expression in the granulosa cells of Hu sheep. Theriogenology, 2020, 157:303-313. |